Dementia experts hail "watershed moment" after trial results for donanemab antibody treatment.

Dementia experts hail “watershed moment” after trial results for donanemab antibody treatment.

  • partial_accumen@lemmy.worldEnglish
    8·
    2 years ago

    It cleared amyloid plaques completely from the brain in some participants, who were then taken off the drug.

    What was the result to the patient outcomes? Did the patients return to pre-demenia state or did their demenia progress simply halt when all the amyloid is cleared (from those patients that got completely cleared of amyloid)?

    • Regna@lemmy.worldEnglish
      1·
      2 years ago

      Sorry, I pressed reply in Voyager, but it ended up as a comment to my post instead of a reply to your comment.

  • Regna@lemmy.worldEnglish
    2·
    2 years ago

    Considering that it is stated that it helped in earlier stages (before they took the patients off donanemab), I don’t think they got as far as claiming it halted the progress. From the article I mainly had the impression that it slowed it enough in some patients to show some progress in the research. Still, this is hopeful, considering the other options that have been available thus far.

    • partial_accumen@lemmy.worldEnglish
      3·
      2 years ago

      That was my conclusion from the article too, but where I’m interested in is if the amyloid build up causes permanent damage to the brain, causing dementia, or with the removal of amyloid (which was never possible before) does the patient gain back anything they lost?

      It seems surprising they left that answer out as it is very compelling to how the disease actually works.